Yes, it is possible mix different media-based building kits on a layout. In fact, it can add a lot of visual interest...
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GWR Hawksworth Auto-Trailer BR Crimson
GWR Hawksworth Auto-Trailer BR Maroon
BR Mk1 BCK Brake Second Corridor Chocolate & Cream
BR Mk2 FK First Corridor BR (SR) Green
LMS Stanier 50ft Full Brake BR Blue & Grey
BR Mk1 Pullman FO First Open (Ex-Second Parlour) BR Blue & Grey
BR Mk1 BSK Brake Second Corridor BR Sealink
BR Mk1 GUV General Utility Van BR Departmental SatLink
BR Mk1 RMB Restaurant Miniature
Class 769 4-Car BiMU 769008 Transport for Wales
N Gauge Autocoach BR Maroon No Insignia W190W
N Gauge Autocoach BR Carmine/Cream No Insignia W193W