Yes, it is possible mix different media-based building kits on a layout. In fact, it can add a lot of visual interest...
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Hornby Dublo EDL17 N2 2 Rail 69567 0-6-2T. OO Gauge USED
Wrenn W2207 Southern Green 1127 Class R1 Tank 0-6-0T Locomotive OO Gauge USED
Wrenn W2204 “LMS 7420” Red Class R1 Tank 0-6-0T Locomotive. OO Gauge Used
Graham Farish 370-250 Diesel tanker freight complete train set with Class 47 locomotive. N Gauge USED
Graham Farish "Merseyside Express" Set incomplete plus extras. N Gauge USED
Hornby R2064B Dean Goods 0-6-0 2526 in GWR Green - Limited Edition for Hornby Collectors Club. OO Gauge USED
Hornby R3555 Class 8P Princess Coronation 4-6-2 46256 "Sir William Stanier F.R.S" in BR maroon. OO Gauge USED
Hornby R2360 Class 5 "Black 5" 4-6-0 44762 in BR Black with late crest (weathered) OO Gauge USED
Hornby R2383 Class 8P 'Princess Coronation' 46521 "City of Nottingham" in BR maroon with late crest - weathered. OO Gauge USED
Hornby R2446 Princess Coronation Class 4-6-2 "Duchess Of Montrose" in BR Green (weathered). OO Gauge USED
Hornby R2229 Class 8F 2-8-0 48154 in BR black with early emblem. OO Gauge USED
Hornby R2102A Class B12/3 4-6-0 61520 in BR lined black. OO Gauge USED