Yes, it is possible mix different media-based building kits on a layout. In fact, it can add a lot of visual interest...
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Family on a Bike Ride (4)
Family Having a Picnic
Gardening (7) Figure Set
At the Wedding Reception
Nude Models (6) Figure
Cyclists (3) Figure Set 1x mail boat on mail bicycle,1x farmer's wife with milk can,1x chimney sweeper with ladder etc.
Anglers (5) Figure Set 1x angler in small wooden boat,4x angler standing on the shore
Marathon Runners (6)
Wedding Guests (6) 2x best man (young woman and young man)Guest with son on his shouldersYoung girl in mini dress (sister of the bride)Photographer with camera at the ready
Wedding Figures (6) 1x Wedding couple standing1x priest (catholic)2x Best man (young man and young woman)1x flower child (girl)
Skiers (6) Figure Set 3x figures on skis3x figures wearing skis
Bobby Car Racers (3) 3 figures on bobby car