Yes, it is possible mix different media-based building kits on a layout. In fact, it can add a lot of visual interest...
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N Gauge M7 0-4-4 Southern Lined Green 37
M7 0-4-4 British Railways Lined Black 30248
M7 0-4-4 Southern Lined Green 37 DCC Fitted
Quarry Hunslet 0-4-0 Tank 'Dorothea' Dorothea Quarry Lined Green
Quarry Hunslet 0-4-0 Tank 'Nesta' Penrhyn Quarry Lined Black
Quarry Hunslet 0-4-0 Tank 'Alice' Dinorwic Quarry Red
MR 3835 4F with Fowler Tender 43931 BR Black (Late Crest) weathered
MR 3835 4F with Fowler Tender 43892 BR Black (British Railways)
MR 3835 4F with Fowler Tender 4057 LMS Black (MR numerals)
Era 4. 1948-1956 British Railways Early Crest
Class 45xx 2-6-2 4566 in GWR green - weathered