Yes, it is possible mix different media-based building kits on a layout. In fact, it can add a lot of visual interest...
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Grounded Van Body kit O gauge Based on LNER 12 ton Goods Van
LMS Meat Van Plstic kitPre-coloured moulded parts
GWR 59' Auto Coach in BR crimson DCC and light bar fitted. Era 4 BR steam Early Crest: 1948-1956Era 5 BR steam Late Crest: 1957-1966
4 Wheel Coach/Brake, green livery